Delays in GABAergic interneuron development and behavioral inhibition after prenatal stress

Delays in GABAergic interneuron development and behavioral inhibition after prenatal stress.

Prenatal stress is associated with altered behavioral, cognitive, and psychiatric outcomes in offspring. Due to the importance of GABAergic systems in normal development and in psychiatric disorders, prenatal stress effects on these neurons have been investigated in animal models. Prenatal stress delays GABAergic progenitor migration, but the significance of these early developmental disruption...

Dlx Gene Regulation of Zebrafish GABAergic Interneuron Development

Prenatal stress and brain development.

Prenatal stress (PS) has been linked to abnormal cognitive, behavioral and psychosocial outcomes in both animals and humans. Animal studies have clearly demonstrated PS effects on the offspring's brain, however, while it has been speculated that PS most likely affects the brains of exposed human fetuses as well, no study has to date examined this possibility prospectively using an independent s...

Stress-induced plasticity of GABAergic inhibition

GABAergic neurotransmission is highly plastic, undergoing dynamic alterations in response to changes in the environment, such as following both acute and chronic stress. Stress-induced plasticity of GABAergic inhibition is thought to contribute to changes in neuronal excitability associated with stress, which is particularly relevant for stress-related disorders and seizure susceptibility. Here...

Exciting times for inhibition: GABAergic synaptic transmission in dentate gyrus interneuron networks

Citation: Ramaswamy S (2015) Exciting times for inhibition: GABAergic synaptic transmission in dentate gyrus interneuron networks. Intricate cognitive functions supported by the cerebral cortex endow mammals with a profound ability to adapt to a constantly changing environment. These sophisticated functions arise as a result of complex synaptic interactions between a myriad of neurons, modulati...